Recent advances in (chemo-)radiation therapy for rectal cancer: a comprehensive review

  • The role of radiation therapy in the treatment of (colo)-rectal cancer has changed dramatically over the past decades. Introduced with the aim of reducing the high rates of local recurrences after conventional surgery, major developments in imaging, surgical technique, systemic therapy and radiation delivery have now created a much more complex environment leading to a more personalized approach. Functional aspects including reduction of acute or late treatment-related side effects, sphincter or even organ-preservation and the unsolved problem of still high distant failure rates have become more important while local recurrence rates can be kept low in the vast majority of patients. This review summarizes the actual role of radiation therapy in different subgroups of patients with rectal cancer, including the current standard approach in different subgroups as well as recent developments focusing on neoadjuvant treatment intensification and/or non-operative treatment approaches aiming at organ-preservation.

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Author:Falk Roeder, Elisa Meldolesi, Sabine Gerum, Vincenzo Valentini, Claus RödelORCiDGND
Parent Title (English):Radiation oncology
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Date of Publication (online):2020/11/10
Date of first Publication:2020/11/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/11/18
Tag:Chemoradiation; Rectal cancer; Review
Issue:Article number: 262
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0