A novel, broad-acting peptide inhibitor of double-stranded DNA virus gene expression and replication

  • Viral infections are a global disease burden with only a limited number of antiviral agents available. Due to newly emerging viral pathogens and increasing occurrence of drug resistance, there is a continuous need for additional therapeutic options, preferably with extended target range. In the present study, we describe a novel antiviral peptide with broad activity against several double-stranded DNA viruses. The 22-mer peptide TAT-I24 potently neutralized viruses such as herpes simplex viruses, adenovirus type 5, cytomegalovirus, vaccinia virus, and simian virus 40 in cell culture models, while being less active against RNA viruses. The peptide TAT-I24 therefore represents a novel and promising drug candidate for use against double-stranded DNA viruses.

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Author:Zsolt Ruzsics, Katja Hoffmann, André Riedl, Adalbert Krawczyk, Marek WideraORCiDGND, Helene Sertznig, Leonie Schipper, Valeria Kapper-Falcone, Monika Debreczeny, Wolfgang Ernst, Reingard Grabherr, Hartmut Hengel, Hanna Harant
URN:urn:nbn:de:hebis:30:3-570152
DOI:https://doi.org/10.3389/fmicb.2020.601555
ISSN:1664-302X
Parent Title (English):Frontiers in microbiology
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Language:English
Date of Publication (online):2020/11/17
Date of first Publication:2020/11/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/12/06
Tag:adenovirus; antiviral peptide; cytomegalovirus; herpes simplex virus; polyomavirus
Volume:11
Issue:601555
Page Number:10
HeBIS-PPN:476955041
Institutes:Medizin / Medizin
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0