Structural and functional diversity calls for a new classification of ABC transporters

  • Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in the nucleotide‐binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs:

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Author:Christoph ThomasORCiD, Stephen G. AllerORCiD, Konstantinos BeisORCiDGND, Elisabeth P. Carpenter, Geoffrey Chang, Lei Chen, Elie Dassa, Michael DeanORCiD, Franck Duong Van Hoa, Damian Ekiert, Robert Ford, Rachelle Gaudet, Xin Gong, I. Barry Holland, Yihua Huang, Daniel K. Kahne, Hiroaki Kato, Vassilis Koronakis, Christopher M. Koth, Youngsook Lee, Oded Lewinson, Roland LillORCiDGND, Enrico Martinoia, Satoshi MurakamiORCiD, Heather W. PinkettORCiD, Bert PoolmanORCiDGND, Daniel Rosenbaum, Balazs Sarkadi, Lutz SchmittORCiDGND, Erwin Schneider, Yigong Shi, Show‐Ling Shyng, Dirk Jan SlotboomORCiDGND, Emad TajkhorshidORCiD, Dirk Peter TielemanORCiDGND, Kazumitsu UedaORCiD, András VáradiORCiD, Po‐Chao WenORCiD, Nieng Yan, Peng Zhang, Hongjin Zheng, Jochen Zimmer, Robert TampéORCiDGND
Parent Title (German):FEBS Letters
Place of publication:Chichester
Document Type:Article
Date of Publication (online):2020/09/26
Date of first Publication:2020/09/26
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/12/10
Tag:ABC transporters; ATPases; X-ray crystallography; cryo-EM; membrane proteins; molecular machines; phylogeny; primary active transporters; sequence alignment; structural biology
Page Number:9
Institutes:Biochemie, Chemie und Pharmazie / Biochemie und Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):License LogoCreative Commons - Namensnennung 4.0