Application of referencing techniques in EEG-based recordings of contact heat evoked potentials (CHEPS)

  • Evoked potentials in the amplitude-time spectrum of the electroencephalogram are commonly used to assess the extent of brain responses to stimulation with noxious contact heat. The magnitude of the N- and P-waves are used as a semi-objective measure of the response to the painful stimulus: the higher the magnitude, the more painful the stimulus has been perceived. The strength of the N-P-wave response is also largely dependent on the chosen reference electrode site. The goal of this study was to examine which reference technique excels both in practical and theoretical terms when analyzing noxious contact heat evoked potentials (CHEPS) in the amplitude-time spectrum. We recruited 21 subjects (10 male, 11 female, mean age of 55.79 years). We applied seven noxious contact heat stimuli using two temperatures, 51°C, and 54°C, to each subject. During EEG analysis, we aimed to identify the referencing technique which produces the highest N-wave and P-wave amplitudes with as little artifactual influence as possible. For this purpose, we applied the following six referencing techniques: mathematically linked A1/A2 (earlobes), average reference, REST, AFz, Pz, and mathematically linked PO7/PO8. We evaluated how these techniques impact the N-P amplitudes of CHEPS based on our data from healthy subjects. Considering all factors, we found that mathematically linked earlobes to be the ideal referencing site to use when displaying and evaluating CHEPS in the amplitude-time spectrum.

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Metadaten
Author:Malte AndersORCiDGND, Björn Anders, Matthias Kreuzer, Sebastian ZinnORCiDGND, Carmen Walter
URN:urn:nbn:de:hebis:30:3-572081
DOI:https://doi.org/10.3389/fnhum.2020.559969
ISSN:1662-5161
Parent Title (English):Frontiers in human neuroscience
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Language:English
Date of Publication (online):2020/12/02
Date of first Publication:2020/12/02
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/12/17
Tag:EEG reference choices; contact heat evoked potentials (CHEPS); electroencephalography (EEG), EEG reference choices, event-related potentials (ERP), independent component analysis (ICA), pain research, contact heat evoked potentials (CHEPS); event-related potentials (ERP); independent component analysis (ICA); pain research
Volume:14
Issue:Article 559969
Page Number:13
Note:
This research was funded by the budget of the Department for Human Experimental Pain Models, Fraunhofer IME. This research was supported by the research funding program Landes-Offensive Zur Entwicklung Wissenschaftlichökonomischer Exzellenz (LOEWE) of the State of Hessen, Research Center for Translational Medicine and Pharmacology (TMP). BA was supported by the EKFS Research Training Group Translational Research Innovation-Pharma (TRIP).
HeBIS-PPN:477472044
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0