Enhanced vigilance stability during daytime in insomnia disorder

  • Central nervous hyperarousal is as a key component of current pathophysiological concepts of chronic insomnia disorder. However, there are still open questions regarding its exact nature and the mechanisms linking hyperarousal to sleep disturbance. Here, we aimed at studying waking state hyperarousal in insomnia by the perspective of resting-state vigilance dynamics. The VIGALL (Vigilance Algorithm Leipzig) algorithm has been developed to investigate resting-state vigilance dynamics, and it revealed, for example, enhanced vigilance stability in depressive patients. We hypothesized that patients with insomnia also show a more stable vigilance regulation. Thirty-four unmedicated patients with chronic insomnia and 25 healthy controls participated in a twenty-minute resting-state electroencephalography (EEG) measurement following a night of polysomnography. Insomnia patients showed enhanced EEG vigilance stability as compared to controls. The pattern of vigilance hyperstability differed from that reported previously in depressive patients. Vigilance hyperstability was also present in insomnia patients showing only mildly reduced sleep efficiency. In this subgroup, vigilance hyperstability correlated with measures of disturbed sleep continuity and arousal. Our data indicate that insomnia disorder is characterized by hyperarousal at night as well as during daytime.

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Metadaten
Author:Ariane Losert, Christian SanderORCiDGND, Michael Schredl, Ivonne Heilmann-Etzbach, Michael DeuschleORCiDGND, Ulrich HegerlORCiDGND, Claudia Schilling
URN:urn:nbn:de:hebis:30:3-574054
DOI:https://doi.org/10.3390/brainsci10110830
ISSN:2076-3425
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/33171860
Parent Title (English):Brain sciences
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2020/11/07
Date of first Publication:2020/11/07
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2020/12/23
Tag:RDoC; arousal; insomnia; polysomnography; resting EEG; vigilance
Volume:10
Issue:Article 830
Page Number:16
HeBIS-PPN:47701545X
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0