Radon exposure - therapeutic effect and cancer risk

  • Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for radiation protection. Nevertheless, radon is also applied for the therapy of inflammatory and degenerative diseases in galleries and spas to many thousand patients a year. In either case, chronic environmental exposure or therapy, the effect of radon on the organism exposed is still under investigation at all levels of interaction. This includes the physical stage of diffusion and energy deposition by radioactive decay of radon and its progeny and the biological stage of initiating and propagating a physiologic response or inducing cancer after chronic exposure. The purpose of this manuscript is to comprehensively review the current knowledge of radon and its progeny on physical background, associated cancer risk and potential therapeutic effects.

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Author:Andreas MaierORCiDGND, Julia WiedemannGND, Felicitas RappORCiDGND, Franziska PapenfußORCiDGND, Franz RödelORCiDGND, Stephanie HehlgansORCiDGND, Udo Sebastian GaiplORCiDGND, Gerhard KraftGND, Claudia FournierORCiDGND, Benjamin FreyORCiD
Parent Title (English):International Journal of Molecular Sciences
Place of publication:Basel
Document Type:Article
Date of Publication (online):2020/12/30
Date of first Publication:2020/12/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/01/06
Tag:anti-inflammatory effects; changes immune activation; clinical studies; low doses; osteoimmunological changes; radon therapy; α-particles
Issue:Article 316
Page Number:39
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0