Case report : symptomatic chronic granulomatous disease in the newborn

  • Chronic granulomatous disease (CGD) is a primary immunodeficiency, which is diagnosed in most patients between one and three years of age. Here we report on a boy who presented at birth with extensive skin lesions and lymphadenopathy which were caused by CGD. An analysis of the literature revealed 24 patients with CGD who became symptomatic during the first six weeks of life. Although pulmonary complications and skin lesions due to infection were the leading symptoms, clinical features were extremely heterogenous. As follow-up was not well specified in most patients, the long-term prognosis of children with very early onset of CGD remains unknown.
Author:Milica Miladinovic, Boris Wittekindt, Sebastian Fischer, Elise GradhandORCiDGND, Steffen Kunzmann, Stefanie-Yvonne Zimmermann, Shahrzad Bakhtiar, Thomas KlingebielORCiDGND, Rolf Schlösser, Thomas LehrnbecherORCiDGND
Parent Title (English):Frontiers in immunology
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Date of Publication (online):2021/03/29
Date of first Publication:2021/03/29
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/06/09
Tag:chronic granulomatous disease; early onset; neonate; outcome; symptoms
Issue:art. 663883
Page Number:9
First Page:1
Last Page:9
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0