Temporal encephaloceles in epilepsy patients and asymptomatic cases: size may indicate epileptogenicity

  • Objective: This study was undertaken to identify temporal encephaloceles (TEs) and examine their characteristics in patients with temporal lobe epilepsy (TLE) and ex- tratemporal lobe epilepsy (ETLE), as well as in asymptomatic cases. Methods: Four hundred fifty-eight magnetic resonance imaging scans were exam- ined retrospectively to identify TE in 157 patients with TLE, 150 patients with ETLE, and 151 healthy controls (HCs). Results: At least one TE was identified in 9.6% of the TLE patients (n = 15, 95% confidence interval [CI] = 5.3%–15.3%), in 3.3% of patients with ETLE (n = 5, 95% CI = 1.1%–7.6%), and in 2.0% of the HCs (n = 3, 95% CI = .4%–5.7%), indicating a significantly higher frequency in patients with TLE compared to ETLE and HC sub- jects (p = .027, p = .005). Examining the characteristics of TEs in both asymptomatic and epilepsy patients, we found that TEs with a diameter of less than 6.25 mm were more likely to be asymptomatic, with a sensitivity of 91.7% and a specificity of 73.3% (area under the curve = .867, 95% CI = .723–1.00, p = .001). Significance: Temporal encephaloceles may occur without presenting any clinical symp- toms. Patients with TLE show a higher frequency of TEs compared to the ETLE and HC groups. According to our study, TE size could be used to suggest potential epileptogenicity.

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Author:Panagiota-Eleni TsalouchidouORCiDGND, Ioannis Mintziras, Louise Biermann, Kristina Krause, Marc-Philipp Bergmann, Marcus BelkeORCiD, Christopher NimskyORCiD, Maximilian Schulze, Adam StrzelczykORCiDGND, Felix RosenowORCiDGND, Katja MenzlerORCiD, Susanne KnakeORCiDGND
URN:urn:nbn:de:hebis:30:3-620932
DOI:https://doi.org/10.1111/epi.16900
ISSN:1528-1167
Parent Title (English):Epilepsia
Publisher:Wiley-Blackwell
Place of publication:Oxford
Document Type:Article
Language:English
Date of Publication (online):2021/05/03
Date of first Publication:2021/05/03
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/08/23
Tag:MRI-negative epilepsy; asymptomatic temporal encephaloceles; epilepsy surgery; temporal encephaloceles; temporal lobe epilepsy
Volume:62
Issue:6
Page Number:8
First Page:1354
Last Page:1361
HeBIS-PPN:486237753
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0