Temporal encephaloceles in epilepsy patients and asymptomatic cases: size may indicate epileptogenicity

  • Objective: This study was undertaken to identify temporal encephaloceles (TEs) and examine their characteristics in patients with temporal lobe epilepsy (TLE) and ex- tratemporal lobe epilepsy (ETLE), as well as in asymptomatic cases. Methods: Four hundred fifty-eight magnetic resonance imaging scans were exam- ined retrospectively to identify TE in 157 patients with TLE, 150 patients with ETLE, and 151 healthy controls (HCs). Results: At least one TE was identified in 9.6% of the TLE patients (n = 15, 95% confidence interval [CI] = 5.3%–15.3%), in 3.3% of patients with ETLE (n = 5, 95% CI = 1.1%–7.6%), and in 2.0% of the HCs (n = 3, 95% CI = .4%–5.7%), indicating a significantly higher frequency in patients with TLE compared to ETLE and HC sub- jects (p = .027, p = .005). Examining the characteristics of TEs in both asymptomatic and epilepsy patients, we found that TEs with a diameter of less than 6.25 mm were more likely to be asymptomatic, with a sensitivity of 91.7% and a specificity of 73.3% (area under the curve = .867, 95% CI = .723–1.00, p = .001). Significance: Temporal encephaloceles may occur without presenting any clinical symp- toms. Patients with TLE show a higher frequency of TEs compared to the ETLE and HC groups. According to our study, TE size could be used to suggest potential epileptogenicity.

Download full text files

Export metadata

Author:Panagiota-Eleni TsalouchidouORCiDGND, Ioannis Mintziras, Louise Biermann, Kristina Krause, Marc-Philipp Bergmann, Marcus Belke, Christopher NimskyORCiD, Maximilian Schulze, Adam StrzelczykORCiDGND, Felix RosenowORCiDGND, Katja Menzler, Susanne KnakeORCiDGND
Parent Title (English):Epilepsia
Place of publication:Oxford
Document Type:Article
Date of Publication (online):2021/05/03
Date of first Publication:2021/05/03
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/08/23
Tag:MRI-negative epilepsy; asymptomatic temporal encephaloceles; epilepsy surgery; temporal encephaloceles; temporal lobe epilepsy
Page Number:8
First Page:1354
Last Page:1361
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0