HDR brachytherapy with individual epithetic molds for facial skin cancer: techniques and first clinical experience

  • Background: Facial skin cancer lesions in close proximity to critical organs require further development of radiotherapeutic techniques for highly conformal treatment, especially when treating elderly frail patients. We report on our treatment technique and first clinical experience for patients with perinasal/periorbital skin cancer treated with individualized epithetic mold high-dose-rate brachytherapy (BRT). Methods: From January 2019, patients with complex shaped or unfavorably located skin cancer not eligible for surgery or external beam radiotherapy (RT) were screened for mold-based BRT. Six patients were identified. Toxicity and clinical response were documented during therapy and posttreatment follow-up. Results: Median patient age was 80 years (74–92 years). Median prescription dose was 42 Gy (range, 33–44 Gy) delivered in once-daily fractions of 3 or 4 Gy. Two patients had treatment interruptions caused by acute conjunctivitis grade 2 and a nontreatment-related cardiac event, respectively. At a median follow-up of 335 days (96–628 days), no ≥ grade 2 late toxicity was documented with all patients showing complete clinical response. Conclusions: High-dose-rate BRT with individualized epithetic molds for perinasal/periorbital skin cancer is a well-tolerated and safe treatment option for patients not eligible for primary surgery or definitive external beam RT because of comorbidities or tumor location.

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Author:Markus DiefenhardtORCiDGND, Georgios ChatzikonstantinouORCiDGND, Markus MeissnerORCiDGND, Janett KöhnGND, Christian ScherfORCiD, Martin Trommel, Jörg LicherGND, Ulla Ramm, Claus RödelORCiDGND, Nikolaos TselisGND
Parent Title (English):International journal of dermatology
Place of publication:Oxford [u.a.]
Document Type:Article
Date of Publication (online):2021/02/27
Date of first Publication:2021/02/27
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/08/25
Page Number:7
First Page:717
Last Page:723
Open Access funding enabled and organized by Projekt DEAL
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0