Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology

  • Although osteoarthritis (OA) is the most common musculoskeletal condition that causes significant health and social problems worldwide, its exact etiology is still unclear. With an aging and increasingly obese population, OA is becoming even more prevalent than in previous decades. Up to 35% of the world’s population over 60 years of age suffers from symptomatic (painful, disabling) OA. The disease poses a tremendous economic burden on the health-care system and society for diagnosis, treatment, sick leave, rehabilitation, and early retirement. Most patients also experience sleep disturbances, reduced capability for exercising, lifting, and walking and are less capable of working, and maintaining an independent lifestyle. For patients, the major problem is disability, resulting from joint tissue destruction and pain. So far, there is no therapy available that effectively arrests structural deterioration of cartilage and bone or is able to successfully reverse any of the existing structural defects. Here, we elucidate novel concepts and hypotheses regarding disease progression and pathology, which are relevant for understanding underlying the molecular mechanisms as a prerequisite for future therapeutic approaches. Emphasis is placed on topographical modeling of the disease, the role of proteases and cytokines in OA, and the impact of the peripheral nervous system and its neuropeptides.

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Author:Susanne GrässelORCiDGND, Frank ZauckeORCiDGND, Henning Madry
Parent Title (English):Journal of Clinical Medicine
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/04/30
Date of first Publication:2021/04/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/09/28
Tag:OA; cartilage; cytokines; inflammation; joint innervation; macrophages; neuropeptides; subchondral bone; synovitis; topographical pattern
Issue:9, art. 1938
Page Number:22
First Page:1
Last Page:22
This research was supported in part by the German Society for Orthopedics and Orthopedic Surgery (DGOOC) with a grant for osteoarthritis related research.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0