High-protein, low-glycaemic meal replacement decreases fasting insulin and inflammation markers - a 12-month subanalysis of the ACOORH trial

  • Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and obesity. Since insulin is the key weight regulator, we hypothesised that the addition of meal replacement to a lifestyle intervention reduces insulin levels more effectively than lifestyle intervention alone. In the international multicentre randomised controlled ACOORH (Almased Concept against Overweight and Obesity and Related Health Risk) trial, overweight or obese persons who meet the criteria for metabolic syndrome (n = 463) were randomised into two groups. Both groups received nutritional advice focusing on carbohydrate restriction and the use of telemonitoring devices. The intervention group substituted all three main meals per day in week 1, two meals per day in weeks 2–4, and one meal per day in weeks 5–26 with a protein-rich, low-glycaemic meal replacement. Data were collected at baseline and after 1, 3, 6 and 12 months. All datasets providing insulin data (n = 446) were included in this predefined subanalysis. Significantly higher reductions in insulin (−3.3 ± 8.7 µU/mL vs. −1.6 ± 9.8 µU/mL), weight (−6.1 ± 5.2 kg vs. −3.2 ± 4.6 kg), and inflammation markers were observed in the intervention group. Insulin reduction correlated with weight reduction and the highest amount of weight loss (−7.6 ± 4.9 kg) was observed in those participants with an insulin decrease > 2 µU/mL. These results underline the potential for meal replacement-based lifestyle interventions in diabetes prevention, and measurement of insulin levels may serve as an indicator for adherence to carbohydrate restriction.

Download full text files

Export metadata

Author:Kerstin KempfORCiDGND, Martin RöhlingORCiDGND, Winfried BanzerGND, Klaus-Michael BraumannORCiDGND, Martin Halle, David McCarthyORCiD, Hans-Georg Predel, Isabelle Schenkenberger, Susanne TanORCiDGND, Hermann ToplakORCiD, Aloys Berg, Stephan Martin
Parent Title (English):Nutrients
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/04/23
Date of first Publication:2021/04/23
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:ACOORH Study Group
Release Date:2021/09/28
Tag:RCT; fasting insulin; lifestyle intervention; low-carbohydrate; low-glycaemic meal replacement; multicentre study; obesity; overweight; protein-rich; weight reduction
Issue:5, art. 1433
Page Number:12
First Page:1
Last Page:12
The study was financially supported by the Almased-Wellness-GmbH. The funder had no influence on study design, data collection, data analysis, manuscript preparation, and/or publication decisions.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0