The macrophage iron signature in health and disease

  • Throughout life, macrophages are located in every tissue of the body, where their main roles are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they promote homeostasis through trophic, regulatory, and repair functions by responding to internal and external stimuli. This in turn polarizes macrophages into a broad spectrum of functional activation states, also reflected in their iron-regulated gene profile. The fast adaptation to the environment in which they are located helps to maintain tissue homeostasis under physiological conditions.

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Author:Christina MertensORCiD, Oriana Marques, Natalie HorvatORCiD, Manuela Simonetti, Martina Muckenthaler, Michaela JungORCiD
URN:urn:nbn:de:hebis:30:3-626342
DOI:https://doi.org/10.3390/ijms22168457
ISSN:1422-0067
Parent Title (English):International journal of molecular sciences
Publisher:Molecular Diversity Preservation International
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2021/08/06
Date of first Publication:2021/08/06
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2021/09/28
Tag:disordered iron metabolism; iron metabolism; macrophage polarization
Volume:22
Issue:16, art. 8457
Page Number:30
First Page:1
Last Page:30
Note:
This research was funded by Wilhelm Sander-Stiftung (2017.130.2, awarded to M.J.). O.M.was supported by a Junior Research Grant from the European Hematology Association O.M. (EHA:RG-70).
HeBIS-PPN:48757740X
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0