Matching quantitative MRI parameters with histological features of treatment-naïve IDH wild-type glioma

  • Quantitative MRI allows to probe tissue properties by measuring relaxation times and may thus detect subtle changes in tissue composition. In this work we analyzed different relaxation times (T1, T2, T2* and T2′) and histological features in 321 samples that were acquired from 25 patients with newly diagnosed IDH wild-type glioma. Quantitative relaxation times before intravenous application of gadolinium-based contrast agent (GBCA), T1 relaxation time after GBCA as well as the relative difference between T1 relaxation times pre-to-post GBCA (T1rel) were compared with histopathologic features such as the presence of tumor cells, cell and vessel density, endogenous markers for hypoxia and cell proliferation. Image-guided stereotactic biopsy allowed for the attribution of each tissue specimen to its corresponding position in the respective relaxation time map. Compared to normal tissue, T1 and T2 relaxation times and T1rel were prolonged in samples containing tumor cells. The presence of vascular proliferates was associated with higher T1rel values. Immunopositivity for lactate dehydrogenase A (LDHA) involved slightly longer T1 relaxation times. However, low T2′ values, suggesting high amounts of deoxyhemoglobin, were found in samples with elevated vessel densities, but not in samples with increased immunopositivity for LDHA. Taken together, some of our observations were consistent with previous findings but the correlation of quantitative MRI and histologic parameters did not confirm all our pathophysiology-based assumptions.

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Author:Gabriele D. MaurerORCiDGND, Julia Frederike TichyGND, Patrick Nikolaus HarterORCiDGND, Ulrike Nöth, Lutz Weise, Johanna Quick-WellerORCiDGND, Ralf DeichmannORCiD, Joachim Peter SteinbachORCiDGND, Oliver Bähr, Elke HattingenORCiDGND
Parent Title (English):Cancers
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/08/12
Date of first Publication:2021/08/12
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/09/28
Tag:glioblastoma; hypoxia; image-guided tissue acquisition; quantitative MRI
Issue:16, art. 4060
Page Number:13
First Page:1
Last Page:13
The project was funded by a young investigator grant to J.T. from the Faculty of Medicine, Goethe University Frankfurt (Patenschaftsmodell). The Senckenberg Institute of Neurooncology was supported by the Senckenberg foundation (grant number 2014/SIN-02).
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0