Growth, proliferation and metastasis of prostate cancer cells is blocked by low-dose curcumin in combination with light irradiation

  • Although anti-cancer properties of the natural compound curcumin have been reported, low absorption and rapid metabolisation limit clinical use. The present study investigated whether irradiation with visible light may enhance the inhibitory effects of low-dosed curcumin on prostate cancer cell growth, proliferation, and metastasis in vitro. DU145 and PC3 cells were incubated with low-dosed curcumin (0.1–0.4 µg/mL) and subsequently irradiated with 1.65 J/cm2 visible light for 5 min. Controls remained untreated and/or non-irradiated. Cell growth, proliferation, apoptosis, adhesion, and chemotaxis were evaluated, as was cell cycle regulating protein expression (CDK, Cyclins), and integrins of the α- and β-family. Curcumin or light alone did not cause any significant effects on tumor growth, proliferation, or metastasis. However, curcumin combined with light irradiation significantly suppressed tumor growth, adhesion, and migration. Phosphorylation of CDK1 decreased and expression of the counter-receptors cyclin A and B was diminished. Integrin α and β subtypes were also reduced, compared to controls. Irradiation distinctly enhances the anti-tumor potential of curcumin in vitro and may hold promise in treating prostate cancer.

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Author:Jochen RutzGND, Aicha Benchellal, Wajdi Kassabra, Sebastian MaxeinerGND, August BerndORCiDGND, Stefan KippenbergerORCiDGND, Nadja Nicole ZöllerORCiDGND, Felix ChunORCiDGND, Eva JüngelORCiDGND, Roman A. BlahetaORCiD
Parent Title (English):International journal of molecular sciences
Publisher:Molecular Diversity Preservation International
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/09/15
Date of first Publication:2021/09/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/12/21
Tag:curcumin; growth; light irradiation; metastasis; proliferation; prostate cancer
Issue:18, art. 9966
Page Number:16
First Page:1
Last Page:16
This research was funded by the Brigitta & Norbert Muth Stiftung, Wiesbaden, Germany.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0