Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis

  • Aim: Assessment of the effect of nonsurgical periodontal therapy on haematological parameters in patients with grades B (BP) and C periodontitis (CP). Methods: Eight BP and 46 CP patients received full-mouth periodontal debridement within 48 h, if positive for Aggregatibacter actinomycetemcomitans with adjunctive systemic antibiotics (4 BP, 17 CP). Clinical data were collected prior and 12 weeks after periodontal therapy. Blood was sampled prior to and 1 day as well as 6 and 12 weeks after the first SD visit. Erythrocyte count, haemoglobin value, haematocrit (HCT), mean erythrocyte volume (MCV), mean corpuscular haemoglobin (MCH), MCH concentration (MCHC), platelets (PLT) and heat shock protein 27 (Hsp27) were assessed. Results: Both groups showed significant clinical improvement (p < 0.05). Using univariate analysis, MCV was noticeably lower in CP than BP at all examinations, HCT only at baseline. For CP, MCHC was noticeably higher 12 weeks after SD than at baseline and 1 day (p ≤ 0.005) and Hsp27 increased noticeably at 1 day (p < 0.05). Repeated measures analysis of variance revealed African origin to be associated with lower MCV and female sex with lower MCHC. Conclusion: Based on multivariate analysis, periodontal diagnosis (BP/CP) was not associated with haematological parameters measured in this study or serum Hsp27. In CP, nonsurgical periodontal therapy improved MCHC 12 weeks after SD. Also in CP Hsp27 was increased 1 day after SD.

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Author:Peter EickholzORCiDGND, Mario Pascal SchröderGND, Anne AsendorfGND, Beate Schacher, Gerhard OremekORCiDGND, Frank Kaiser, Martin WohlfeilGND, Luigi NibaliGND
Parent Title (English):Clinical oral investigations
Place of publication:Berlin ; Heidelberg
Document Type:Article
Date of Publication (online):2020/05/08
Date of first Publication:2020/05/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/12/12
Tag:Haematocrit; Heat shock protein 27; Mean erythrocyte volume; Number of platelets; Periodontitis grades B and C
Page Number:9
First Page:4291
Last Page:4299
Open Access funding provided by Projekt DEAL. This study was in part funded by the authors and their institutions and in part by grants of the German Society of Periodontology (DG PARO), the German Society of Dental, Oral, and Maxillofacial Medicine (DGZMK), the New Working Group for Periodontology (NAgP) (3 months examination) and the Freiherr Carl von Rothschild’sche Stiftung Carolinum, Frankfurt, Germany (analysis for heat shock proteins).
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0