Staged implant placement after defect regeneration using biphasic calcium phosphate materials with different surface topographies in a minipig model

  • Objective: To assess the influence of biphasic calcium phosphate materials with different surface topographies on bone formation and osseointegration of titanium implants in standardized alveolar ridge defects. Materials and methods: Standardized alveolar ridge defects (6 × 6 mm) were created in the mandible of 8 minipigs and filled with three biphasic calcium phosphate materials (BCP1–3, 90% tricalcium phosphate/10% hydroxyapatite) with different surface properties (micro- and macroporosities) as well as a bovine-derived natural bone mineral (NBM) as a control. At 12 weeks, implants were placed into the augmented defects. After further 8 weeks of healing, dissected blocks were processed for histological analysis (e.g., mineralized (MT), residual bone graft material (BS), bone-to-implant contact (BIC)). Results: All four biomaterials showed well-integrated graft particles and new bone formation within the defect area. MT values were comparable in all groups. BS values were highest in the NBM group (21.25 ± 13.52%) and markedly reduced in the different BCP groups, reaching statistical significance at BCP1-treated sites (9.2 ± 3.28%). All test and control groups investigated revealed comparable and statistically not significant different BIC values, ranging from 73.38 ± 20.5% (BCP2) to 84.11 ± 7.84% (BCP1), respectively. Conclusion* All bone graft materials facilitated new bone formation and osseointegration after 12 + 8 weeks of healing.
Author:Ilja MihatovicGND, Frank SchwarzORCiDGND, Karinna Anne-Marie ObrejaORCiDGND, Jürgen BeckerGND, Robert Alexander SaderORCiDGND, Michel Marcel DardORCiD, Gordon JohnORCiDGND
Parent Title (English):Clinical oral investigations
Place of publication:Berlin ; Heidelberg
Document Type:Article
Date of Publication (online):2020/01/24
Date of first Publication:2020/01/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/07/05
Tag:Animal model; Bone remodelling; Bone substitute; Histological analysis; Implant osseointegration
Page Number:10
First Page:3289
Last Page:3298
Open Access funding provided by Projekt DEAL. This study was funded by Institute Straumann AG, Basel, Switzerland.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0