Long noncoding RNAs in cardiometabolic disorders

  • The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging-related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in the pancreas, liver, adipose tissue, and skeletal muscle impairs glucose and lipid metabolism, and mitochondrial function, triggering the development of diabetes and lipid-related disorders that inflict damage on cardiac and vascular tissues. Long noncoding RNAs (lncRNAs) regulate a wide range of biological process and are one of the key factors controlling metabolism and mitochondria. Here, we discuss the versatile function of lncRNAs involved in the metabolic regulation of glucose and lipid, and mitochondrial function, and how the dysregulation of lncRNAs induces the development of various metabolic disorders and their cardiovascular consequences.
Metadaten
Author:Rio P. JuniORCiD, Kelly C. 't HartORCiD, Riekelt H. HoutkooperORCiD, Reinier BoonORCiDGND
URN:urn:nbn:de:hebis:30:3-639807
DOI:https://doi.org/10.1002/1873-3468.14370
ISSN:1873-3468
Parent Title (English):FEBS letters
Publisher:Wiley
Place of publication:Chichester
Document Type:Article
Language:English
Date of Publication (online):2022/05/09
Date of first Publication:2022/05/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/12/20
Tag:LncRNA; aging; cardiovascular system; glucose and lipid metabolism; mitochondria
Volume:596
Issue:11
Page Number:21
First Page:1367
Last Page:1387
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International

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