Ectonucleoside triphosphate diphosphohydrolases and ecto-5'-nucleotidase in purinergic signaling: how the field developed and where we are now
- Geoffrey Burnstock will be remembered as the scientist who set up an entirely new field of intercellular communication, signaling via nucleotides. The signaling cascades involved in purinergic signaling include intracellular storage of nucleotides, nucleotide release, extracellular hydrolysis, and the effect of the released compounds or their hydrolysis products on target tissues via specific receptor systems. In this context ectonucleotidases play several roles. They inactivate released and physiologically active nucleotides, produce physiologically active hydrolysis products, and facilitate nucleoside recycling. This review briefly highlights the development of our knowledge of two types of enzymes involved in extracellular nucleotide hydrolysis and thus purinergic signaling, the ectonucleoside triphosphate diphosphohydrolases, and ecto-5′-nucleotidase.
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| Author: | Herbert ZimmermannORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-635790 |
| DOI: | https://doi.org/10.1007/s11302-020-09755-6 |
| ISSN: | 1573-9546 |
| Parent Title (English): | Purinergic signalling |
| Publisher: | Springer Science + Business Media B.V. |
| Place of publication: | Dordrecht |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/12/17 |
| Date of first Publication: | 2020/12/17 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/03/03 |
| Tag: | ATP; Adenosine; E-NTPDase; Ecto-5'-nucleotidase; Geoffrey Burnstock; History |
| Volume: | 17 |
| Issue: | 1 |
| Page Number: | 9 |
| First Page: | 117 |
| Last Page: | 125 |
| Note: | Open Access funding enabled and organized by Projekt DEAL. |
| HeBIS-PPN: | 507185560 |
| Institutes: | Biowissenschaften |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
