Prolonged antibiotic prophylaxis in tissue reconstruction using autologous fat grafting: is there a benefit for wound healing?

  • Fat grafting is a well-established method in plastic surgery. Despite many technical advances, standardised recommendations for the use of prophylactic antibiotics in fat grafting are not available. This retrospective multicentre study aims to analyse the use of prophylactic antibiotics in fat grafting and to compare complication rates for different protocols. A retrospective medical chart review of 340 patients treated with fat grafting of the breast from January 2007 to March 2019 was performed in three plastic surgery centres. Complications, outcomes, and antibiotic regimes were analysed. The Clavien-Dindo classification was applied. All patients received perioperative antibiotic prophylaxis: 33.8% (n = 115) were treated with a single shot (group 1), 66.2% (n = 225) received a prolonged antibiotic scheme (group 2). There was no significant difference in the number of sessions (P = .475). The overall complication rate was 21.6% (n = 75), including graft resorption, fat necrosis, infection, and wound healing problems. Complication rates were not significantly different between groups. Risk factors for elevated complication rates in this specific patient group are smoking, chemotherapy, and irradiation therapy. The complication rate for lipografting of the breast is low, and it is not correlated to the antibiotic protocol. The use of prolonged prophylactic antibiotics does not lower the complication rate.

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Author:Evi M. MorandiORCiD, Selina WinkelmannORCiD, Lucie Dostal, Isabel RadackiGND, Ulrich RiegerORCiDGND, Benedikt BauerORCiD, Ralph VerstappenORCiDGND, Dolores WolframORCiD, Thomas Bauer
URN:urn:nbn:de:hebis:30:3-723925
DOI:https://doi.org/10.1111/iwj.13638
ISSN:1742-481X
Parent Title (English):International wound journal
Publisher:Wiley-Blackwell
Place of publication:Oxford [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2021/06/09
Date of first Publication:2021/06/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/04/25
Tag:antibiotic prophylaxis; fat grafting; lipofilling; tissue reconstruction; wound healing
Volume:19.2021
Issue:2
Page Number:9
First Page:380
Last Page:388
Note:
The data that support the findings of this study are available from the corresponding author upon reasonable request.
HeBIS-PPN:508902401
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International