Repurposing of the antibiotic nitroxoline for the treatment of mpox

  • The antiviral drugs tecovirimat, brincidofovir, and cidofovir are considered for mpox (monkeypox) treatment despite a lack of clinical evidence. Moreover, their use is affected by toxic side-effects (brincidofovir, cidofovir), limited availability (tecovirimat), and potentially by resistance formation. Hence, additional, readily available drugs are needed. Here, therapeutic concentrations of nitroxoline, a hydroxyquinoline antibiotic with a favourable safety profile in humans, inhibited the replication of 12 mpox virus isolates from the current outbreak in primary cultures of human keratinocytes and fibroblasts and a skin explant model by interference with host cell signalling. Tecovirimat, but not nitroxoline, treatment resulted in rapid resistance development. Nitroxoline remained effective against the tecovirimat-resistant strain and increased the anti-mpox virus activity of tecovirimat and brincidofovir. Moreover, nitroxoline inhibited bacterial and viral pathogens that are often co-transmitted with mpox. In conclusion, nitroxoline is a repurposing candidate for the treatment of mpox due to both antiviral and antimicrobial activity.

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Author:Denisa BojkovaORCiDGND, Nadja Nicole ZöllerORCiDGND, Manuela TietgenORCiDGND, Katja Steinhorst, Marco Bechtel, Tamara RothenburgerORCiD, Joshua D. KandlerORCiD, Julia SchneiderORCiD, Victor Max CormanORCiDGND, Sandra CiesekORCiDGND, Holger RabenauORCiDGND, Mark N. WassORCiD, Stefan KippenbergerORCiDGND, Stephan GöttigORCiDGND, Martin MichaelisORCiDGND, Jindrich CinatlORCiDGND
Parent Title (English):Journal of Medical Virology
Place of publication:Bognor Regis [u.a.]
Document Type:Article
Date of Publication (online):2023/03/10
Date of first Publication:2023/03/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/09/03
Tag:antiviral drugs; antiviral therapy; chelator; drug repurposing; monkeypox; orthopoxvirus; poxvirus
Issue:3, e28652
Page Number:13
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International