Radioimmunotherapy: future prospects from the perspective of brachytherapy

  • In combination with radiotherapy, immunotherapy is becoming an increasingly used strategy in treating advanced, recurrent, or metastatic cancer. The evident impact of radiotherapy on local and systemic immune response is an indication of the synergistic effect of these two modalities. There is a strong rationale to combine radiotherapy and immunotherapy to enhance response rates and overcome resistances. Therefore, the combination of radio- and immunotherapy holds a variety of opportunities as well as challenges in treating primary cancer and is progressively tested in curative settings. Brachytherapy is also known as internal radiation therapy and only offers a local therapy option at first glance: due to tumor-specific antigens, released by a high local radiation dose, a systemic immune response could be plausible and eminent. Accordingly, brachytherapy could be an underestimated partner with immuno-therapeutic approaches in both curative and palliative settings, to generate local and systemic response. In this review, we summarized the potential benefit of a potential combination of brachytherapy and immuno-therapeutic approaches vs. the background of limited data.

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Author:Maximilian FleischmannGND, Markus GlatzerORCiD, Claus RödelORCiDGND, Nikolaos TselisGND
Parent Title (English):Journal of contemporary brachytherapy
Place of publication:Poznań
Document Type:Article
Date of Publication (online):2021/08/24
Date of first Publication:2021/08/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/11/28
Tag:abscopal effect; brachytherapy; immunotherapy; radioimmunotherapy
Page Number:10
First Page:458
Last Page:467
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY-NC-SA - Namensnennung - Nicht kommerziell - Weitergabe unter gleichen Bedingungen 4.0 International