Extracellular matrix remodeling in chronic liver disease

  • Purpose of the Review: This review aims to summarize the current knowledge of the extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions of the extracellular matrix with hepatic cells and the surrounding matrix in liver fibrosis, with the focus on the molecular pathways and the mechanisms that regulate extracellular matrix remodeling. Recent Findings: The extracellular matrix not only provides structure and support for the cells, but also controls cell behavior by providing adhesion signals and by acting as a reservoir of growth factors and cytokines. Summary: Hepatic fibrosis is characterized by an excessive accumulation of extracellular matrix. During fibrogenesis, the natural remodeling process of the extracellular matrix varies, resulting in the excessive accumulation of its components, mainly collagens. Signals released by the extracellular matrix induce the activation of hepatic stellate cells, which are the major source of extracellular matrix and most abundant myofibroblasts in the liver.

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Author:Cristina OrtizORCiD, Robert SchierwagenORCiDGND, Liliana SchäferORCiD, Sabine KleinORCiD, Xavier TrepatORCiD, Jonel TrebickaORCiDGND
Parent Title (English):Current tissue microenvironment reports
Publisher:Springer International Publishing
Place of publication:Cham
Document Type:Article
Date of Publication (online):2021/07/23
Date of first Publication:2021/07/23
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/11/23
Tag:Collagen; Extracellular matrix; Hepatic stellate cell; Liver fibrosis; Metalloproteinases; TGF-β1
Page Number:12
First Page:41
Last Page:52
Open Access funding enabled and organized by Projekt DEAL.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International