Anti-cancer effect of kaffir lime (Citrus Hystrix DC) leaf extract in cervical cancer and neuroblastoma cell lines

  • Previous study showed that kaffir lime leaf contains alkaloid, flavonoid, terpenoid, tannin and saponin. The objective of this study was to examine the cytotoxic effect of kaffir lime leaf extract on cervical cancer and neuroblastoma cell lines. The method used for this research to determine cell viability was an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results showed that an ethyl acetate extract had an IC50 for HeLa cells, UKF-NB3, IMR-5 and SK-N-AS parental cells of 40.7 μg · mL–1, 28.4 μg · mL–1, 14.1 μg · mL–1, and 25.2 μg · mL–1 respectively. Furthermore, the IC50 of chloroform extracts for HeLa cells, UKF-NB3, IMR-5 and SK-N-AS parental were 17.6 μg · mL–1, 18.9 μg · mL–1, 6.4 μg · mL–1, and 9.4 μg · mL–1 respectively. These data showed that kaffir lime extract reduces the viability of cervical and neuroblastoma cell lines and may have potential as anti-cancer compounds.

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Author:Woro Anindito Sri TunjungORCiD, Jindrich CinatlORCiDGND, Martin MichaelisORCiDGND, Christopher Mark SmalesORCiD
Parent Title (English):Procedia Chemistry
Place of publication:Amsterdam [u.a.]
Document Type:Conference Proceeding
Year of Completion:2015
Year of first Publication:2015
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:2nd Humboldt Kolleg in conjunction with International Conference on Natural Sciences, HK-ICONS 2014
Release Date:2023/09/19
Tag:MTT assay; cervical cancer; kaffir lime; neuroblastoma
Page Number:4
First Page:465
Last Page:468
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International