Mechanisms and physiological functions of ER-phagy

  • The endoplasmic reticulum (ER) is the largest cellular organelle that undergoes constant turnover upon diverse functional demands and cellular signals. Removal of nonfunctional or superfluous subdomains is balanced by the parallel expansion and formation of ER membranes, leading to the dynamic exchange of ER components. In recent years, selective autophagy of the ER, termed ER-phagy, has emerged as a predominant process involved in ER degradation and maintenance of ER homeostasis. Identification of multiple ER-phagy receptors, many with additional ER-shaping functions, paved the way for our molecular understanding of ER turnover in different cells and organs. In this review, we describe the molecular principles underling the physiological functions of ER-phagy in maintaining ER homeostasis via receptor-mediated macroautophagy and elaborate current focus points of the field.

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Metadaten
Author:Pablo Sanz-Martinez, Alexandra StolzORCiDGND
URN:urn:nbn:de:hebis:30:3-764051
DOI:https://doi.org/10.1016/j.cophys.2022.100613
ISSN:2468-8673
Parent Title (English):Current Opinion in Physiology
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Date of Publication (online):2022/11/18
Date of first Publication:2022/11/04
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2023/10/20
Volume:30
Issue:100613
Article Number:100613
Page Number:6
HeBIS-PPN:514482230
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International