In vitro models of bone marrow remodelling and immune dysfunction in space: present state and future directions

  • Spaceflight affects the body on every level. Reports on astronaut health identify bone marrow remodelling and dysfunction of the innate immune system as significant health risks of long-term habitation in space. Microgravity-induced alterations of the bone marrow induce physical changes to the bone marrow stem cell niche. Downstream effects on innate immunity are expected due to impaired hematopoiesis and myelopoiesis. To date, few studies have investigated these effects in real microgravity and the sparsely available literature often reports contrasting results. This emphasizes a need for the development of physiologically relevant in vitro models of the bone marrow stem cell niche, capable of delivering appropriate sample sizes for robust statistics. Here, we review recent findings on the impact of spaceflight conditions on innate immunity in in vitro and animal models and discusses the latest in vitro models of the bone marrow stem cell niche and their potential translatability to gravitational biology research.

Download full text files

Export metadata

Metadaten
Author:Ryan SarkarORCiD, Francesco PampaloniORCiDGND
URN:urn:nbn:de:hebis:30:3-692894
DOI:https://doi.org/10.3390/biomedicines10040766
ISSN:2227-9059
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/35453515
Parent Title (English):Biomedicines
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2022/03/24
Date of first Publication:2022/03/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/05/06
Tag:3D cell culture; bone marrow niche; hematopoiesis; hematopoietic progenitor cells; innate immunity; mesenchymal stem cells; microgravity; myelopoiesis
Volume:10
Issue:4, art. 766
Article Number:766
Page Number:25
First Page:1
Last Page:25
Note:
This work was supported by the European Space Agency through Grant/Award Number: CORA-GBF-2017-001 and the Deutsches Zentrum für Luft- und Raumfahrt (German Aerospace Center) through grant 50WB2019. The publication fees were supported by the Open Access Fund of Goethe Universität Frankfurt am Main.
Institutes:Fachübergreifende Einrichtungen / Buchmann Institut für Molekulare Lebenswissenschaften (BMLS)
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International