Relationship between regional white matter hyperintensities and alpha oscillations in older adults

  • Aging is associated with increased white matter hyperintensities (WMHs) and with the alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N=907, 60-80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and LRTC. Finally, higher age was associated with elevated alpha power via total WMH volume. Although an increase in alpha oscillations due to WMH can have a compensatory nature, we rather suggest that an elevated alpha power is a consequence of WMH affecting a spatial organization of alpha sources.

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Metadaten
Author:Deniz KumralORCiDGND, Elena CesnaiteORCiD, Frauke BeyerORCiDGND, Simon M. HofmannORCiD, Tilman HenschORCiDGND, Christian SanderORCiDGND, Ulrich HegerlORCiDGND, Stefan HaufeORCiD, Arno VillringerORCiDGND, A. Veronica WitteORCiDGND, Vadim NikulinORCiD
URN:urn:nbn:de:hebis:30:3-728903
URL:https://www.biorxiv.org/content/10.1101/2020.09.04.283200v3
DOI:https://doi.org/10.1101/2020.09.04.283200
Parent Title (English):bioRxiv
Publisher:bioRxiv
Document Type:Preprint
Language:English
Date of Publication (online):2021/05/13
Date of first Publication:2021/05/13
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/04/08
Tag:EEG; MRI; aging; alpha power; resting-state; white matter hyperintensity
Issue:2020.09.04.283200 Version 3
Edition:Version 3
Page Number:48
HeBIS-PPN:517664224
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International