Management and treatment options for patients with de novo and recurrent hormone-sensitive oligometastatic prostate cancer

  • Probably, patients with de novo (synchronous) and recurrent (metachronous) oligometastatic hormone-sensitive prostate cancer have different oncologic outcomes. Thus, we are challenged with different scenarios in clinical practice, where different treatment options may apply. In the last years, several prospective studies have focused on the treatment of patients with de novo oligometastatic hormone-sensitive prostate cancer. Not only the addition of systemic therapeutic treatments, such as chemotherapy with docetaxel, abiraterone, enzalutamide, and apalutamide, next to androgen deprivation therapy, demonstrated to improve outcomes in these patients but also local therapy of the primary has been demonstrated to improve outcomes of low-volume metastatic disease. Next to radiotherapy, also radical prostatectomy has been reported as a feasible and safe treatment option. Additional metastasis-directed therapy in de novo metastatic disease is currently examined by four trials. In the recurrent metastatic setting, less data are available, and it remains uncertain if patients can be treated in the same way as synchronous oligometastatic disease. Metastasis-directed therapy has demonstrated to prolong outcomes, while data on survival are still missing.

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Metadaten
Author:Felix PreißerORCiDGND, Felix ChunORCiDGND, Séverine BanekGND, Mike WenzelORCiDGND, Markus GraefenORCiDGND, Thomas SteuberGND, Derya TilkiORCiDGND, Philipp MandelORCiDGND
URN:urn:nbn:de:hebis:30:3-779671
DOI:https://doi.org/10.1016/j.prnil.2020.12.003
ISSN:2287-8882
Parent Title (English):Prostate international
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Date of Publication (online):2021/09/29
Date of first Publication:2021/01/18
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/02/07
Tag:Local therapy; Metastasis-directed therapy; Oligometastatic; Prostate cancer; Systemic therapy
Volume:9
Issue:3
Page Number:6
First Page:113
Last Page:118
HeBIS-PPN:520983165
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International