EphrinB2-EphB4 signaling in neurooncological disease
- EphrinB2–EphB4 signaling is critical during embryogenesis for cardiovascular formation and neuronal guidance. Intriguingly, critical expression patterns have been discovered in cancer pathologies over the last two decades. Multiple connections to tumor migration, growth, angiogenesis, apoptosis, and metastasis have been identified in vitro and in vivo. However, the molecular signaling pathways are manifold and signaling of the EphB4 receptor or the ephrinB2 ligand is cancer type specific. Here we explore the impact of these signaling pathways in neurooncological disease, including glioma, brain metastasis, and spinal bone metastasis. We identify potential downstream pathways that mediate cancer suppression or progression and seek to understand it´s role in antiangiogenic therapy resistance in glioma. Despite the Janus-faced functions of ephrinB2–EphB4 signaling in cancer Eph signaling remains a promising clinical target.
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| Author: | András PiffkóORCiDGND, Christian UhlORCiDGND, Peter VajkoczyORCiDGND, Marcus Alexander CzabankaORCiDGND, Thomas BrogginiORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-810258 |
| DOI: | https://doi.org/10.3390/ijms23031679 |
| ISSN: | 1422-0067 |
| Parent Title (English): | International journal of molecular sciences |
| Publisher: | Molecular Diversity Preservation International |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2022/01/31 |
| Date of first Publication: | 2022/01/31 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2024/02/02 |
| Tag: | EphB4; bone; bone metastasis; brain metastasis; ephrinB2; glioblastoma; glioma; metastasis; neurooncology; spinal metastasis |
| Volume: | 23 |
| Issue: | 3, art. 1679 |
| Article Number: | 1679 |
| Page Number: | 17 |
| First Page: | 1 |
| Last Page: | 17 |
| Note: | This research was funded by the German research foundation DFG GEPRIS: 267716524 and the FOR2325 DFG Forschergruppe. |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
