Molecular markers to predict prognosis and treatment response in uterine cervical cancer

  • Uterine cervical cancer is one of the leading causes of cancer-related mortality in women worldwide. Each year, over half a million new cases are estimated, resulting in more than 300,000 deaths. While less-invasive, fertility-preserving surgical procedures can be offered to women in early stages, treatment for locally advanced disease may include radical hysterectomy, primary chemoradiotherapy (CRT) or a combination of these modalities. Concurrent platinum-based chemoradiotherapy regimens remain the first-line treatments for locally advanced cervical cancer. Despite achievements such as the introduction of angiogenesis inhibitors, and more recently immunotherapies, the overall survival of women with persistent, recurrent or metastatic disease has not been extended significantly in the last decades. Furthermore, a broad spectrum of molecular markers to predict therapy response and survival and to identify patients with high- and low-risk constellations is missing. Implementation of these markers, however, may help to further improve treatment and to develop new targeted therapies. This review aims to provide comprehensive insights into the complex mechanisms of cervical cancer pathogenesis within the context of molecular markers for predicting treatment response and prognosis.

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Author:Maximilian FleischmannGND, Georgios ChatzikonstantinouORCiDGND, Emmanouil FokasORCiDGND, Jörn WichmannORCiDGND, Hans ChristiansenGND, Klaus StrebhardtORCiDGND, Claus RödelORCiDGND, Nikolaos TselisGND, Franz RödelORCiDGND
URN:urn:nbn:de:hebis:30:3-822772
DOI:https://doi.org/10.3390/cancers13225748
ISSN:2072-6694
Parent Title (English):Cancers
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2021/11/17
Date of first Publication:2021/11/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/02/22
Tag:biomarker; cervical cancer; chemoradiotherapy; molecular marker; outcome; predictive; prognostic; response; survival
Volume:13
Issue:22, art. 5748
Article Number:5748
Page Number:28
First Page:1
Last Page:28
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International