The corpus adiposum infrapatellare (Hoffa’s fat pad) - the role of the infrapatellar fat pad in osteoarthritis pathogenesis

  • In recent years, the infrapatellar fat pad (IFP) has gained increasing research interest. The contribution of the IFP to the development and progression of knee osteoarthritis (OA) through extensive interactions with the synovium, articular cartilage, and subchondral bone is being considered. As part of the initiation process of OA, IFP secretes abundant pro-inflammatory mediators among many other factors. Today, the IFP is (partially) resected in most total knee arthroplasties (TKA) allowing better visualization during surgical procedures. Currently, there is no clear guideline providing evidence in favor of or against IFP resection. With increasing numbers of TKAs, there is a focus on preventing adverse postoperative outcomes. Therefore, anatomic features, role in the development of knee OA, and consequences of resecting versus preserving the IFP during TKA are reviewed in the following article.

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Author:Sebastian Benedict BraunORCiDGND, Frank ZauckeORCiDGND, Marco Uwe BrenneisORCiDGND, Anna Elise RappORCiDGND, Patrizia PollingerGND, Rebecca SohnORCiD, Zsuzsa Jenei-LanzlORCiDGND, Andrea MeurerORCiD
URN:urn:nbn:de:hebis:30:3-823769
DOI:https://doi.org/10.3390/biomedicines10051071
ISSN:2227-9059
Parent Title (English):Biomedicines
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2022/05/05
Date of first Publication:2022/05/05
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/02/22
Tag:fat pad resection; inflammation; infrapatellar fat pad; knee osteoarthritis; total knee replacement
Volume:10
Issue:5, art. 1071
Article Number:1071
Page Number:16
First Page:1
Last Page:16
Note:
This study was supported by a grant of the Deutsche Forschungsgemeinschaft (to Z.J.-L., JE 642/4-1, JE 642/4-2; project number 277277765) within the DFG Research Unit FOR2407 ExCarBon.
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International

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