Antioxidants as therapeutic aAgents in acute respiratory distress syndrome (ARDS) treatment - from mice to men
- Acute respiratory distress syndrome (ARDS) is a major cause of patient mortality in intensive care units (ICUs) worldwide. Considering that no causative treatment but only symptomatic care is available, it is obvious that there is a high unmet medical need for a new therapeutic concept. One reason for a missing etiologic therapy strategy is the multifactorial origin of ARDS, which leads to a large heterogeneity of patients. This review summarizes the various kinds of ARDS onset with a special focus on the role of reactive oxygen species (ROS), which are generally linked to ARDS development and progression. Taking a closer look at the data which already have been established in mouse models, this review finally proposes the translation of these results on successful antioxidant use in a personalized approach to the ICU patient as a potential adjuvant to standard ARDS treatment.
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| Author: | Andreas von KnethenORCiDGND, Ulrike Elisabeth Brigitte HeinickeGND, Volker LauxORCiD, Michael J. ParnhamORCiDGND, Andrea U. SteinbickerORCiDGND, Kai ZacharowskiORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-825027 |
| DOI: | https://doi.org/10.3390/biomedicines10010098 |
| ISSN: | 2227-9059 |
| Parent Title (English): | Biomedicines |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2022/01/04 |
| Date of first Publication: | 2022/01/04 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2024/02/27 |
| Tag: | ARDS; GSH; NADPH oxidase; Nrf2; SOD; antioxidant; electron transfer chain |
| Volume: | 10 |
| Issue: | 1, art. 98 |
| Article Number: | 98 |
| Page Number: | 24 |
| First Page: | 1 |
| Last Page: | 24 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
