Relationship between regional white matter hyperintensities and alpha oscillations in older adults

  • Objective: To investigate whether regional white matter hyperintensities (WMHs) relate to alpha oscillations (AO) in a large population-based sample of elderly individuals. Methods: We associated voxel-wise WMHs from high-resolution 3-Tesla MRI with neuronal alpha oscillations (AO) from resting-state multichannel EEG at sensor (N=907) and source space (N=855) in older participants of the LIFE-Adult study (60–80 years). In EEG, we computed relative alpha power (AP), individual alpha peak frequency (IAPF), as well as long-range temporal correlations (LRTC) that represent dynamic properties of the signal. We implemented whole-brain voxel-wise regression models to identify regions where parameters of AO were linked to probability of WMH occurrence. We further used mediation analyses to examine whether WMH volume mediated the relationship between age and AO. Results: Higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. The age-related increase of relative AP in the right temporal brain region was shown to be mediated by total WMH volume. Conclusion: A high relative AP corresponding to increased regional WMHs was not associated with age per se, in fact, this relationship was mediated by WMHs. We argue that the WMH-associated increase of AP reflects a generalized and likely compensatory spread of AO leading to a larger number of synchronously recruited neurons. Our findings thus suggest that longitudinal EEG recordings might be sensitive to detect functional changes due to WMHs.

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Metadaten
Author:Deniz KumralORCiDGND, Elena CesnaiteORCiD, Frauke BeyerORCiDGND, Simon M. HofmannORCiD, Tilman HenschORCiDGND, Christian SanderORCiDGND, Ulrich HegerlORCiDGND, Stefan HaufeORCiD, Arno VillringerORCiDGND, A. Veronica WitteORCiDGND, Vadim NikulinORCiD
URN:urn:nbn:de:hebis:30:3-835767
URL:https://www.biorxiv.org/content/10.1101/2020.09.04.283200v1
DOI:https://doi.org/10.1101/2020.09.04.283200
Parent Title (English):bioRxiv
Publisher:bioRxiv
Document Type:Preprint
Language:English
Date of Publication (online):2020/09/06
Date of first Publication:2020/09/06
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/04/08
Issue:2020.09.04.283200 Version 1
Edition:Version 1
Page Number:29
HeBIS-PPN:517862751
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International