Distinct contributions of the dorsal and ventral hippocampus to spatial working memory and spatial coding in the prefrontal cortex

  • The hippocampus (HPC) supports spatial working memory (SWM) through its interactions with the prefrontal cortex (PFC). However, it is not clear whether and how the dorsal (dHPC) and ventral (vHPC) poles of the HPC make distinct contributions to SWM and whether they differentially influence the PFC. To address this question, we optogenetically silenced the dHPC or the vHPC while simultaneously recording from the PFC of mice performing a SWM task. We found that whereas both HPC subregions were necessary during the encoding phase of the task, only the dHPC was necessary during the choice phase. Silencing of either subregion altered the spatial firing patterns of PFC neurons. However, only silencing of the vHPC affected their coding of spatial goals. These results thus reveal distinct contributions of the dorsal and ventral HPC poles to SWM and the coding of behaviorally-relevant spatial information by PFC neurons.

Download full text files

Export metadata

Metadaten
Author:Susanne BablORCiDGND, Torfi SigurdssonORCiD
URN:urn:nbn:de:hebis:30:3-869059
URL:https://www.biorxiv.org/content/10.1101/2024.08.16.607133v1
DOI:https://doi.org/10.1101/2024.08.16.607133
Parent Title (English):bioRxiv
Publisher:bioRxiv
Document Type:Preprint
Language:English
Date of Publication (online):2024/08/16
Date of first Publication:2024/08/16
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/09/03
Issue:2024.08.16.607133v1
Edition:Version 1
Page Number:37
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International

OPUS4 Logo