- For acute and chronic soft tissue infections, radical surgical debridement is required and is considered the gold standard, along with its immediate systemic antibiotic therapy. Treatment with local antibiotics and/or antibiotic-containing materials is commonly used as an additional tool in clinical practice. Spraying with fibrin and antibiotics is a newer technique that has been studied for some antibiotics. However, for gentamicin, data are not yet available on absorption, optimal application, antibiotic fate at the site and transfer of antibiotic into the blood. In an animal study involving 29 Sprague Dawley rats, 116 back wounds were sprayed with gentamicin using either gentamicin alone or one of two possible spray combinations of gentamicin and fibrin. Simultaneous application of gentamicin and fibrin via a spray system to soft tissue wounds resulted in significant antibiotic concentration over a long period of time. The technique is easy and cost-effective. The systemic crossover was significantly minimized in our study, which may have led to fewer side effects in patients. These results could lead to an improvement in local antibiotic therapy.
MetadatenAuthor: | Meike B. Kejwal, René VerboketORCiDGND, Katharina SommerGND, Fabian DustGND, Dominique Jeanette ThomasORCiDGND, Philipp StörmannORCiDGND, Johannes FrankORCiDGND, Dirk HenrichORCiDGND, Ingo MarziORCiDGND, Maren JankoORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-869406 |
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DOI: | https://doi.org/10.3390/jcm12103390 |
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ISSN: | 2077-0383 |
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Parent Title (English): | Journal of Clinical Medicine |
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Publisher: | MDPI |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2023/05/10 |
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Date of first Publication: | 2023/05/10 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2024/09/18 |
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Tag: | SSTI; acute infections; animal model; chronic infections; fibrin-glue-spray technique; local antibiotics; soft tissue |
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Volume: | 12 |
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Issue: | 10, art. 3390 |
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Article Number: | 3390 |
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Page Number: | 10 |
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First Page: | 1 |
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Last Page: | 10 |
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Note: | Gefördert durch den Open-Access-Publikationsfonds der Goethe-Universität. |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Open-Access-Publikationsfonds: | Medizin |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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