Ambulatory routine care in oncology in Germany: real-world survival data

  • Introduction: Survival data reported by randomised controlled trials are collected in a highly selected patient population and can thus only be transferred to a limited extent to real-world patients: the patients in routine care are mostly older, present with more comorbidities and a worse general state of health. This so-called efficacy-effectiveness gap typically results in inferior survival data in routine healthcare. Methods: Six prospective clinical tumour registries recruited a total of 11,679 patients receiving systemic therapy in haemato-oncological practices in Germany between 2006 and 2020. For these patients with advanced colorectal cancer, breast cancer, lung cancer, pancreatic cancer, renal cell cancer, and lymphatic neoplasms, overall survival was analysed. A comprehensive literature search was performed to identify suitable pivotal randomised controlled trials. Results: Median overall survival of patients treated in German routine care, with advanced colorectal, breast, lung, and pancreatic cancer, as well as with diffuse large B-cell lymphoma and multiple myeloma, is not shorter than the respective survival data reported in trials. Patients with advanced renal cell carcinoma, chronic lymphocytic leukaemia, or indolent non-Hodgkin lymphoma showed slightly lower survival rates compared to clinical trials. Conclusions: Despite less favourable patient characteristics, survival data from patients with cancer treated in ambulatory routine care in Germany are in range with results from randomised controlled studies.

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Metadaten
Author:Norbert MarschnerORCiD, Wolfgang KnaufGND
URN:urn:nbn:de:hebis:30:3-869450
DOI:https://doi.org/10.1159/000536652
ISSN:2296-5270
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/38493778
Parent Title (English):Oncology Research and Treatment
Publisher:Karger
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2024/03/15
Date of first Publication:2024/03/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/09/05
Tag:Cancer registries; Cohort study; Oncology; Outpatient care; Overall survival; Real-world data
Volume:47
Issue:7-8
Page Number:11
First Page:340
Last Page:350
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International