Molecular mechanism of membrane sensing
- In this thesis, molecular dynamics (MD) simulations are used to study the interaction of different proteins with lipid bilayers. MD simulations can be used as a “computational microscope” to gain atomistic insights into the interactions between proteins and lipids that can barely be accessed in such detail by experimental methods. The different chapters of this thesis address the lipid sensing functionality of amphipathic helices (AHs) when bound to membranes, the folding of AHs at lipid-water interfaces as well as the conformational dynamics of the HIV-1 Env glycoproteins in viral-like and experimental bilayers. In the last chapter the possibilities to enhance the performance of MD simulations are explored, leading to a more efficient usage of computational resources.
| Author: | Michael GechtORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-657573 |
| DOI: | https://doi.org/10.21248/gups.65757 |
| Place of publication: | Frankfurt am Main |
| Referee: | Volker DötschORCiDGND, Gerhard HummerORCiD |
| Document Type: | Doctoral Thesis |
| Language: | English |
| Date of Publication (online): | 2022/01/25 |
| Year of first Publication: | 2021 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Granting Institution: | Johann Wolfgang Goethe-Universität |
| Date of final exam: | 2021/12/13 |
| Release Date: | 2022/02/11 |
| Page Number: | 172 |
| Last Page: | 149 |
| HeBIS-PPN: | 490930425 |
| Institutes: | Biochemie, Chemie und Pharmazie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Deutsches Urheberrecht |
