TY  - JOUR
A1  - Abs, Elisabeth
A1  - Poorthuis, Rogier B.
A1  - Apelblat, Daniella
A1  - Muhammad, Karzan
A1  - Pardi, M. Belen
A1  - Enke, Leona
A1  - Kushinsky, Dahlia
A1  - Pu, De-Lin
A1  - Eizinger, Max Ferdinand
A1  - Conzelmann, Karl-Klaus
A1  - Spiegel, Ivo
A1  - Letzkus, Johannes J.
T1  - Learning-related plasticity in dendrite-targeting layer 1 interneurons
T2  - Neuron
N2  - A wealth of data has elucidated the mechanisms by which sensory inputs are encoded in the neocortex, but how these processes are regulated by the behavioral relevance of sensory information is less understood. Here, we focus on neocortical layer 1 (L1), a key location for processing of such top-down information. Using Neuron-Derived Neurotrophic Factor (NDNF) as a selective marker of L1 interneurons (INs) and in vivo 2-photon calcium imaging, electrophysiology, viral tracing, optogenetics, and associative memory, we find that L1 NDNF-INs mediate a prolonged form of inhibition in distal pyramidal neuron dendrites that correlates with the strength of the memory trace. Conversely, inhibition from Martinotti cells remains unchanged after conditioning but in turn tightly controls sensory responses in NDNF-INs. These results define a genetically addressable form of dendritic inhibition that is highly experience dependent and indicate that in addition to disinhibition, salient stimuli are encoded at elevated levels of distal dendritic inhibition.
KW  - neocortical circuits
KW  - GABAergic interneurons
KW  - layer 1
KW  - interneurons
KW  - NDNF interneurons
KW  - somatostatin interneurons
KW  - dendritic inhibition
KW  - genetic markers
KW  - connectivity
KW  - top-down processing
KW  - fear learning
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48356
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-483569
SN  - 1097-4199
SN  - 0896-6273
N1  - This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
VL  - 100
IS  - 3
SP  - 684
EP  - 699.e6
PB  - Cell Press ; Elsevier
CY  - [Cambridge, Mass.] ; New York, NY
ER  -