TY  - JOUR
A1  - Maturová, M.
A1  - Beckmann, Helga
A1  - Wacker, Adolf
T1  - Hemmung der steroidabhängigen Enzyminduktion bei Pseudomonas testosteroni mit Alkaloiden
T2  - Zeitschrift für Naturforschung, B
N2  - Induction of the enzyme Δ5-3-ketosteroid isomerase in Pseudomonas testosteroni was found to be strongly inhibited by reserpine and by the alkaloids of Vinca and Ergot. Morphine, colchicine and papaverine caused weaker inhibition whilst a series of other alkaloids were almost ineffective. Ergot alkaloids were inhibitory towards all steroids tested, androgens, oestrogens and progestagens, and a similar effect was shown with the other inducible enzymes, 3α- and 3β.17β-hydroxysteroid-dehydrogenase.
Experiments with cell-free protein synthesis indicate that reserpine inhibits the induction of messenger RNA.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/74875
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-748758
SN  - 1865-7117
SN  - 0932-0776
VL  - 22.1967
IS  - 6
SP  - 621
EP  - 626
PB  - Verlag der Zeitschrift für Naturforschung
CY  - Tübingen
ER  -