TY  - JOUR
A1  - Sanz-Martinez, Pablo
A1  - Stolz, Alexandra
T1  - Mechanisms and physiological functions of ER-phagy
T2  - Current Opinion in Physiology
N2  - The endoplasmic reticulum (ER) is the largest cellular organelle that undergoes constant turnover upon diverse functional demands and cellular signals. Removal of nonfunctional or superfluous subdomains is balanced by the parallel expansion and formation of ER membranes, leading to the dynamic exchange of ER components. In recent years, selective autophagy of the ER, termed ER-phagy, has emerged as a predominant process involved in ER degradation and maintenance of ER homeostasis. Identification of multiple ER-phagy receptors, many with additional ER-shaping functions, paved the way for our molecular understanding of ER turnover in different cells and organs. In this review, we describe the molecular principles underling the physiological functions of ER-phagy in maintaining ER homeostasis via receptor-mediated macroautophagy and elaborate current focus points of the field.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76405
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-764051
SN  - 2468-8673
VL  - 30
IS  - 100613
PB  - Elsevier
CY  - Amsterdam
ER  -