TY - JOUR A1 - Holder, Jana A1 - Trinler, Ursula A1 - Meurer, Andrea A1 - Stief, Felix T1 - A systematic review of the associations between inverse dynamics and musculoskeletal modeling to investigate joint loading in a clinical environment T2 - Frontiers in Bioengineering and Biotechnology N2 - The assessment of knee or hip joint loading by external joint moments is mainly used to draw conclusions on clinical decision making. However, the correlation between internal and external loads has not been systematically analyzed. This systematic review aims, therefore, to clarify the relationship between external and internal joint loading measures during gait. A systematic database search was performed to identify appropriate studies for inclusion. In total, 4,554 articles were identified, while 17 articles were finally included in data extraction. External joint loading parameters were calculated using the inverse dynamics approach and internal joint loading parameters by musculoskeletal modeling or instrumented prosthesis. It was found that the medial and total knee joint contact forces as well as hip joint contact forces in the first half of stance can be well predicted using external joint moments in the frontal plane, which is further improved by including the sagittal joint moment. Worse correlations were found for the peak in the second half of stance as well as for internal lateral knee joint contact forces. The estimation of external joint moments is useful for a general statement about the peak in the first half of stance or for the maximal loading. Nevertheless, when investigating diseases as valgus malalignment, the estimation of lateral knee joint contact forces is necessary for clinical decision making because external joint moments could not predict the lateral knee joint loading sufficient enough. Dependent on the clinical question, either estimating the external joint moments by inverse dynamics or internal joint contact forces by musculoskeletal modeling should be used. KW - musculoskeletal modeling KW - inverse dynamics KW - gait analysis KW - joint contact forces KW - joint moments KW - knee joint KW - hip joint Y1 - 2020 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57561 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-575618 SN - 2296-4185 N1 - This work was supported by the German Research Foundation (DFG) (Project number: 403837822). Sponsor had no involvement in this article. VL - 8 IS - art. 603907 SP - 1 EP - 18 PB - Frontiers Media CY - la ER -