TY  - JOUR
A1  - Heyl, Andreas Stephan
A1  - Luu, Brigitte
A1  - Wieszner, Markus
A1  - Nikkhoo, Aria
A1  - Seeger, Florian Hartmut
A1  - Hemmann, Katrin
A1  - Aßmus, Birgit
A1  - Kaess, Bernhard
A1  - Zeiher, Andreas M.
A1  - Walther, Claudia
A1  - Fichtlscherer, Stephan
A1  - Honold, Jörg Florian Hannes
T1  - Differential prognostic accuracy of right ventricular dysfunction, the Seattle heart failure model and the MAGGIC score in patients with severe mitral regurgitation undergoing the MitraClip® procedure
T2  - International journal of cardiology
N2  - Background: MitraClip ® (MC) is an established procedure for severe mitral regurgitation (MR) in patients deemed unsuitable for surgery. Right ventricular dysfunction (RVD) is associated with a higher mortality risk. The prognostic accuracy of heart failure risk scores like the Seattle heart failure model (SHFM) and Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score in pts undergoing MC with or without RVD has not been investigated so far. Methods: SHFM and MAGGIC score were calculated retrospectively. RVD was determined as tricuspid annular plane systolic excursion (TAPSE) ≤15 mm. Area under receiver operating curves (AUROC) of SHFM and MAGGIC were performed for one-year all-cause mortality after MC. Results: N = 103 pts with MR III° (73 ± 11 years, LVEF 37 ± 17%) underwent MC with a reduction of at least I° MR. One-year mortality was 28.2%. In Kaplan-Meier analysis, one- year mortality was significantly higher in RVD-pts (34.8% vs 2.8%, p = 0.009). Area under the Receiver Operating Characteristic (AUROC) for SHFM and MAGGIC were comparable for both scores (SHFM: 0.704, MAGGIC: 0.692). In pts without RVD, SHFM displayed a higher AUROC and therefore better diagnostic accuracy (SHFM: 0.776; MAGGIC: 0.551, p < 0.05). In pts with RVD, MAGGIC and SHFM displayed comparable AUROCs. Conclusion: RVD is an important prognostic marker in pts undergoing MC. SHFM and MAGGIC displayed adequate over-all prognostic power in these pts. Accuracy differed in pts with and without RVD, indicating higher predictive power of the SHFM score in pts without RVD.
KW  - MitraClip
KW  - Seattle heart failure model
KW  - MAGGIC score
KW  - TAPSE
KW  - Functional mitral regurgitation
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62359
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-623599
SN  - 2352-9067
VL  - 31
IS  - art. 100641
SP  - 1
EP  - 8
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  -