TY  - JOUR
A1  - Gechter, Johanna
A1  - Liebscher, Carolin
A1  - Geiger, Maximilian J.
A1  - Wittmann, André
A1  - Schlagenhauf, Florian
A1  - Lüken, Ulrike
A1  - Wittchen, Hans-Ulrich
A1  - Pfleiderer, Bettina
A1  - Arolt, Volker
A1  - Kircher, Tilo
A1  - Straube, Benjamin
A1  - Deckert, Jürgen
A1  - Weber, Heike
A1  - Herrmann, Martin J.
A1  - Reif, Andreas
A1  - Domschke, Katharina
A1  - Ströhle, Andreas
T1  - Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls
T2  - NeuroImage: Clinical
N2  - Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli.
Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety.
Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC).
Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG.
KW  - Panic disorder
KW  - Agoraphobia
KW  - NPSR1
KW  - Imaging genetics
KW  - fMRI
KW  - Westphal-Paradigm
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51799
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-517991
SN  - 2213-1582
N1  - © 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
VL  - 24
IS  - Art. 102029
SP  - 1
EP  - 8
PB  - Elsevier
CY  - [Amsterdam u. a.]
ER  -