TY  - JOUR
A1  - Qubad, Mishal
A1  - Barnes-Scheufler, Catherine
A1  - Schaum, Michael
A1  - Raspor, Eva
A1  - Rösler, Lara
A1  - Peters, Benjamin
A1  - Schiweck, Carmen
A1  - Goebel, Rainer
A1  - Reif, Andreas
A1  - Bittner, Robert Arthur
T1  - Improved correspondence of fMRI visual field localizer data after cortex-based macroanatomical alignment
T2  - Scientific Reports
N2  - Studying the visual system with fMRI often requires using localizer paradigms to define regions of interest (ROIs). However, the considerable interindividual variability of the cerebral cortex represents a crucial confound for group-level analyses. Cortex-based alignment (CBA) techniques reliably reduce interindividual macroanatomical variability. Yet, their utility has not been assessed for visual field localizer paradigms, which map specific parts of the visual field within retinotopically organized visual areas. We evaluated CBA for an attention-enhanced visual field localizer, mapping homologous parts of each visual quadrant in 50 participants. We compared CBA with volume-based alignment and a surface-based analysis, which did not include macroanatomical alignment. CBA led to the strongest increase in the probability of activation overlap (up to 86%). At the group level, CBA led to the most consistent increase in ROI size while preserving vertical ROI symmetry. Overall, our results indicate that in addition to the increased signal-to-noise ratio of a surface-based analysis, macroanatomical alignment considerably improves statistical power. These findings confirm and extend the utility of CBA for the study of the visual system in the context of group analyses. CBA should be particularly relevant when studying neuropsychiatric disorders with abnormally increased interindividual macroanatomical variability.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/79546
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-795461
SN  - 2045-2322
VL  - 12
IS  - Article number: 14310
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - [London]
ER  -