TY - JOUR A1 - Phuyal, Parbati A1 - Kramer, Isabelle Marie A1 - Klingelhöfer, Doris A1 - Kuch, Ulrich A1 - Magdeburg, Axel A1 - Groneberg, Jan David Alexander A1 - Wouters, Edwin A1 - Dhimal, Meghnath A1 - Müller, Ruth T1 - Spatiotemporal distribution of dengue and chikungunya in the Hindu Kush Himalayan region: a systematic review T2 - International journal of environmental research and public health N2 - The risk of increasing dengue (DEN) and chikungunya (CHIK) epidemics impacts 240 million people, health systems, and the economy in the Hindu Kush Himalayan (HKH) region. The aim of this systematic review is to monitor trends in the distribution and spread of DEN/CHIK over time and geographically for future reliable vector and disease control in the HKH region. We conducted a systematic review of the literature on the spatiotemporal distribution of DEN/CHIK in HKH published up to 23 January 2020, following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. In total, we found 61 articles that focused on the spatial and temporal distribution of 72,715 DEN and 2334 CHIK cases in the HKH region from 1951 to 2020. DEN incidence occurs in seven HKH countries, i.e., India, Nepal, Bhutan, Pakistan, Bangladesh, Afghanistan, and Myanmar, and CHIK occurs in four HKH countries, i.e., India, Nepal, Bhutan, and Myanmar, out of eight HKH countries. DEN is highly seasonal and starts with the onset of the monsoon (July in India and June in Nepal) and with the onset of spring (May in Bhutan) and peaks in the postmonsoon season (September to November). This current trend of increasing numbers of both diseases in many countries of the HKH region requires coordination of response efforts to prevent and control the future expansion of those vector-borne diseases to nonendemic areas, across national borders. KW - epidemics KW - monsoon KW - postmonsoon KW - public health Y1 - 2020 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56122 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-561224 SN - 1660-4601 N1 - © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). VL - 17 IS - 18, art. 6656 SP - 1 EP - 18 PB - MDPI CY - Basel ER -