TY  - JOUR
A1  - Aksan, Aysegül
A1  - Farrag, Karima
A1  - Blumenstein, Irina Ursula
A1  - Schröder, Oliver
A1  - Dignass, Axel Uwe
A1  - Stein, Jürgen
T1  - Chronic intestinal failure and short bowel syndrome in Crohn’s disease
T2  - World journal of gastroenterology
N2  - Chronic intestinal failure (CIF) is a rare but feared complication of Crohn’s disease. Depending on the remaining length of the small intestine, the affected intestinal segment, and the residual bowel function, CIF can result in a wide spectrum of symptoms, from single micronutrient malabsorption to complete intestinal failure. Management of CIF has improved significantly in recent years. Advances in home-based parenteral nutrition, in particular, have translated into increased survival and improved quality of life. Nevertheless, 60% of patients are permanently reliant on parenteral nutrition. Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy. The outcomes of patients with CIF could be greatly improved by more effective prevention, understanding, and treatment. In complex cases, the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation, nutritional support, and an improved quality of life. Here, we summarize current literature on CIF and short bowel syndrome, encompassing epidemiology, pathophysiology, and advances in surgical and medical management, and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease.
KW  - Chronic intestinal failure
KW  - Short bowel syndrome
KW  - Crohn's disease
KW  - Inflammatory bowel disease
KW  - Parenteral nutrition
KW  - Intestinal failure-associated liver disease
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/58078
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-580781
SN  - 1007-9327
SN  - 2219-2840
VL  - 27
IS  - 24
SP  - 3440
EP  - 3465
PB  - Baishideng Publishing Group Inc.
CY  - Beijing
ER  -