TY  - JOUR
A1  - Morandi, Evi M.
A1  - Winkelmann, Selina
A1  - Dostal, Lucie
A1  - Radacki, Isabel
A1  - Rieger, Ulrich
A1  - Bauer, Benedikt
A1  - Verstappen, Ralph
A1  - Wolfram, Dolores
A1  - Bauer, Thomas
T1  - Prolonged antibiotic prophylaxis in tissue reconstruction using autologous fat grafting: is there a benefit for wound healing?
T2  - International wound journal
N2  - Fat grafting is a well-established method in plastic surgery. Despite many technical advances, standardised recommendations for the use of prophylactic antibiotics in fat grafting are not available. This retrospective multicentre study aims to analyse the use of prophylactic antibiotics in fat grafting and to compare complication rates for different protocols. A retrospective medical chart review of 340 patients treated with fat grafting of the breast from January 2007 to March 2019 was performed in three plastic surgery centres. Complications, outcomes, and antibiotic regimes were analysed. The Clavien-Dindo classification was applied. All patients received perioperative antibiotic prophylaxis: 33.8% (n = 115) were treated with a single shot (group 1), 66.2% (n = 225) received a prolonged antibiotic scheme (group 2). There was no significant difference in the number of sessions (P = .475). The overall complication rate was 21.6% (n = 75), including graft resorption, fat necrosis, infection, and wound healing problems. Complication rates were not significantly different between groups. Risk factors for elevated complication rates in this specific patient group are smoking, chemotherapy, and irradiation therapy. The complication rate for lipografting of the breast is low, and it is not correlated to the antibiotic protocol. The use of prolonged prophylactic antibiotics does not lower the complication rate.
KW  - antibiotic prophylaxis
KW  - fat grafting
KW  - lipofilling
KW  - tissue reconstruction
KW  - wound healing
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72392
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-723925
SN  - 1742-481X
N1  - The data that support the findings of this study are available from the corresponding author upon reasonable request.
VL  - 19.2021
IS  - 2
SP  - 380
EP  - 388
PB  - Wiley-Blackwell
CY  - Oxford [u.a.]
ER  -