TY  - JOUR
A1  - Mihatovic, Ilja
A1  - Schwarz, Frank
A1  - Obreja, Karinna Anne-Marie
A1  - Becker, Jürgen
A1  - Sader, Robert Alexander
A1  - Dard, Michel Marcel
A1  - John, Gordon
T1  - Staged implant placement after defect regeneration using biphasic calcium phosphate materials with different surface topographies in a minipig model
T2  - Clinical oral investigations
N2  - Objective: To assess the influence of biphasic calcium phosphate materials with different surface topographies on bone formation and osseointegration of titanium implants in standardized alveolar ridge defects.
Materials and methods: Standardized alveolar ridge defects (6 × 6 mm) were created in the mandible of 8 minipigs and filled with three biphasic calcium phosphate materials (BCP1–3, 90% tricalcium phosphate/10% hydroxyapatite) with different surface properties (micro- and macroporosities) as well as a bovine-derived natural bone mineral (NBM) as a control. At 12 weeks, implants were placed into the augmented defects. After further 8 weeks of healing, dissected blocks were processed for histological analysis (e.g., mineralized (MT), residual bone graft material (BS), bone-to-implant contact (BIC)).
Results: All four biomaterials showed well-integrated graft particles and new bone formation within the defect area. MT values were comparable in all groups. BS values were highest in the NBM group (21.25 ± 13.52%) and markedly reduced in the different BCP groups, reaching statistical significance at BCP1-treated sites (9.2 ± 3.28%). All test and control groups investigated revealed comparable and statistically not significant different BIC values, ranging from 73.38 ± 20.5% (BCP2) to 84.11 ± 7.84% (BCP1), respectively.
Conclusion* All bone graft materials facilitated new bone formation and osseointegration after 12 + 8 weeks of healing.
KW  - Bone remodelling
KW  - Bone substitute
KW  - Histological analysis
KW  - Implant osseointegration
KW  - Animal model
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63784
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-637844
SN  - 1436-3771
N1  - Open Access funding provided by Projekt DEAL. This study was funded by Institute Straumann AG, Basel, Switzerland.
VL  - 24.2020
IS  - 9
SP  - 3289
EP  - 3298
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -