TY  - JOUR
A1  - Weigert, Andreas
A1  - Olesch, Catherine
A1  - Brüne, Bernhard
T1  - Sphingosine-1-phosphate and macrophage biology—how the sphinx tames the big eater
T2  - Frontiers in immunology
N2  - The sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to either signal through intracellular targets or to activate a family of specific G-protein-coupled receptors (S1PR). S1P levels are usually low in peripheral tissues compared to the vasculature, forming a gradient that mediates lymphocyte trafficking. However, S1P levels rise during inflammation in peripheral tissues, thereby affecting resident or recruited immune cells, including macrophages. As macrophages orchestrate initiation and resolution of inflammation, the sphingosine kinase/S1P/S1P-receptor axis emerges as an important determinant of macrophage function in the pathogenesis of inflammatory diseases such as cancer, atherosclerosis, and infection. In this review, we therefore summarize the current knowledge how S1P affects macrophage biology.
KW  - sphingosine-1-phosphate
KW  - macrophages
KW  - macrophage polarization
KW  - cancer
KW  - atherosclerosis
KW  - infection
KW  - inflammation
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50759
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-507597
SN  - 1664-3224
N1  - Copyright © 2019 Weigert, Olesch and Brüne. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 10
IS  - Art. 1706
SP  - 1
EP  - 19
PB  - Frontiers Media
CY  - Lausanne
ER  -