TY  - JOUR
A1  - Bird, Alex D.
A1  - Cuntz, Hermann
T1  - Dissecting sholl analysis into its functional components
T2  - Cell Reports
N2  - Sholl analysis has been an important technique in dendritic anatomy for more than 60 years. The Sholl intersection profile is obtained by counting the number of dendritic branches at a given distance from the soma and is a key measure of dendritic complexity; it has applications from evaluating the changes in structure induced by pathologies to estimating the expected number of anatomical synaptic contacts. We find that the Sholl intersection profiles of most neurons can be reproduced from three basic, functional measures: the domain spanned by the dendritic arbor, the total length of the dendrite, and the angular distribution of how far dendritic segments deviate from a direct path to the soma (i.e., the root angle distribution). The first two measures are determined by axon location and hence microcircuit structure; the third arises from optimal wiring and represents a branching statistic estimating the need for conduction speed in a neuron.
KW  - Sholl analysis
KW  - root angle
KW  - dendrite
KW  - morphology
KW  - connectivity
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77504
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-775047
SN  - 2211-1247
VL  - 27
IS  - 10
SP  - 3081
EP  - 3096.e5
PB  - Elsevier
CY  - Amsterdam
ER  -