TY  - JOUR
A1  - Oreb, Igor-Mislav
A1  - Dietz, Heiko
A1  - Farwick, Alexander
A1  - Boles, Eckhard
T1  - Novel strategies to improve co-fermentation of pentoses with D-glucose by recombinant yeast strains in lignocellulosic hydrolysates
T2  - Bioengineered
N2  - Economically feasible production of second-generation biofuels requires efficient co-fermentation of pentose and hexose sugars in lignocellulosic hydrolysates under very harsh conditions. Baker’s yeast is an excellent, traditionally used ethanol producer but is naturally not able to utilize pentoses. This is due to the lack of pentose-specific transporter proteins and enzymatic reactions. Thus, natural yeast strains must be modified by genetic engineering. Although the construction of various recombinant yeast strains able to ferment pentose sugars has been described during the last two decades, their rates of pentose utilization is still significantly lower than D-glucose fermentation. Moreover, pentoses are only fermented after D-glucose is exhausted, resulting in an uneconomical increase in the fermentation time. In this addendum, we discuss novel approaches to improve utilization of pentoses by development of specific transporters and substrate channeling in enzyme cascades. Addendum to: T Subtil, E Boles. Competition between pentoses and glucose during uptake and catabolism in recombinant Saccharomyces cerevisiae. Biotechnol Biofuels 2012; 5: 14
PMID: 22424089 DOI: 10.1186/1754-6834-5-14
KW  - bioethanol
KW  - co-fermentation of pentoses with glucose
KW  - substrate channeling
KW  - sugar transport
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28861
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-288612
N1  - Copyright © 2012 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
VL  - 3
IS  - 6
SP  - 347
EP  - 351
PB  - Landes Bioscience
CY  - Austin, Tex.
ER  -